National Yang Ming Chiao Tung University

Institute of Statistics




Hsiuying Wang




Room 422, Assemble Building 1




+886-3-571-2121ext 56813



·         EDUCATION

o        Ph.D. Statistics, National Tsing Hua University, 1996.

o        M.S. Mathematics, National Taiwan University, 1990.

o        B.S. Mathematics, National Taiwan University, 1988.


·         EXPERIENCE

o        Professor, Institute of Statistics, National Chiao Tung University, Taiwan, 2008-present.

o        Associate Research Fellow, Institute of Statistical Science, Academia Sinica 2002-2008.

o        Assistant  Research Fellow,  Institute of Statistical Science, Academia Sinica 1998-2002.

o        Associate  Professor,  Department of Business Administration, Chaoyang University of Technology 1996-1998.



o        Guest Editor: Frontiers in Bioscience (2018), Cells (2018), Current Pharmaceutical Design (2019), Frontiers in Neurology (2020), Biomolecules (2020), Processes (2021-), Polymers (2021-), Cells (2022-)

o        Reviewer Board: Processes (2021), Symmetry (2021)

o        Topic Editor: Biomolecules, Cells, Genes, International Journal of Molecular Sciences, Non-Coding RNA (2022-)

o        Editor, 中國統計學報 (Journal of the Chinese Statistical Association), 2016.8-2018.7.

o        Editorial Board: Frontiers in Genetics (2020-)

        Frontiers in Oncology (2022-)

        Scientific Reports (2023-)

·         HONORS

Full Member 2023, Sigma Xi, The Scientific Research Honor Society




Statistical interval estimation, Bioinformatics, Signal recognition, miRNA



  1. Wang, H.* (2023). Anti-NMDA receptor encephalitis, human papillomavirus, and microRNA. Current Medicinal Chemistry, accepted. (SCI)

  2. Wang, H.* (2023). The Potential of Collagen Treatment for Comorbid Diseases. Polymers, 15(19):3999. (SCI) Link

  3. Wang, H.* (2023). MicroRNA pathological mechanisms between Parkinson's disease, Alzheimer's disease, glaucoma and macular degeneration. Expert Reviews in Molecular Medicine, 25, E24. (SCI) Link

  4. Wang, H.* (2023). Tolerance limits for mixture-of-normal distributions with application to COVID-19 data. Wiley Interdisciplinary Reviews: Computational Statistics, e1611. (SCI)

  5. Wang, H.* (2023). Biomaterials in Medical Applications. Polymers, 15, 847. (SCI)

  6. Wang, H.* and Ho, C. (2023). The Human Pre-miRNA Distance Distribution for Exploring Disease Association. International Journal of Molecular Sciences, 24(2), 1009. (SCI)

  7. Wang, H.* (2022). The distance distribution of human microRNAs in MirGeneDB database. Scientific Reports, 12, 17696. (SCI)

  8. Chen, W. and Wang, H.* (2022). Phylogenetic Tree Selection by Testing Substitution Number in Clade. Diversity, 14(7), 543. (SCI)

  9. Fu, S. C., Shih, L. C., Wu, P. H., Hsieh, Y. C., Lee, C. H., Lin, S. H.* and Wang, H.* (2022). Exploring the Causal Effect of Constipation on Parkinson’s Disease Through Mediation Analysis of Microbial Data. Frontiers in Cellular and Infection Microbiology, 498. (SCI)

  10. Fu, S. C., Lee, C. H., Hsieh, Y. C., Wu, P. H., Lin, S. H.* and Wang, H.* (2022). A Pilot Study Exploring the Association of Entacapone, Gut Microbiota, and the Subsequent Side Effects in Patients With Parkinson’s Disease. Frontiers in cellular and infection microbiology, 12. (SCI)

  11. Lee, C-H and Wang, H.* (2022). Multiple imputation confidence intervals for the mean of the discrete distributions for incomplete data. Statistics in Medicine, 30;41(7):1172-1190. (SCI)

  12. Wang, H.* (2022). COVID-19, Anti-NMDA Receptor Encephalitis and MicroRNA. Frontiers in Immunology, 13:825103. (SCI)

  13. Lai, B. R., and Wang, H. (2021). Monitoring change points by a sign change method. Behavioral Predictive Modeling in Economics. Springer, Cham, 153-170.

  14. Wang, H.* and Y.-H. Chen (2021). microRNA Biomarkers in Clinical Study (Editorial), Biomolecules, 11(12). (SCI)

  15. Wang, H.* (2021). A Review of the Effects of Collagen Treatment in Clinical Studies. Polymers, 13, 22: 3868. (SCI)

  16. Wang, H.* (2021). MicroRNAs, Multiple Sclerosis, and Depression. International Journal of Molecular Sciences, 22(15), 7802. (SCI)

  17. Wang, H.*, Taguchi, Y. H. and Liu, X. (2021) Editorial: miRNAs and Neurological Diseases. Frontiers in Neurology, 12. (SCI)

  18. Wang, H.* (2021). MicroRNAs, Parkinson's Disease, and Diabetes Mellitus. International Journal of Molecular Sciences, 22(6), 2953. (SCI)

  19. Fu S-C, Lee C-H, Wang H.* (2021). Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome. International Journal of Environmental Research and Public Health, 18(2):667. (SCI)

  20. Wang, H.* (2021). The Generalized Bayes Method for High-Dimensional Data Recognition with Applications to Audio Signal Recognition . Symmetry, 13(1), 19 (SCI)

  21. Wang, H.* (2021). Phylogenetic Analysis of microRNA Biomarkers for Amyotrophic Lateral Sclerosis. Biocell, 45,547-561. (SCI)

  22. Chen, Y.H. and Wang, H.* (2021). The association between migraine and depression based on miRNA biomarkers and cohort studies. Current Medicinal Chemistry, 28, 1-9. (SCI)  PDF 

  23. Lee, C.-H. and Wang, H.* (2021). Confidence Intervals for the Proportion of Conformance. Journal of Statistical Computation and Simulation, 91, 8, 1564-1579. (SCI)

  24. Chen, Y.-H. and Wang, H.* (2020). The association between depression and gastroesophageal reflux based on phylogenetic analysis of miRNA biomarkers, Current Medicinal Chemistry, 27(38), 6536-6547. (SCI)  PDF 

  25. Chen. C. and Wang, H.* (2020). Logistic Regression Method for Ligand Discovery, Journal of Computational Biology, 27, 6, 934–940 (SCI)

  26. Wang, H.* (2020) MicroRNA, Diabetes Mellitus and Colorectal Cancer. Biomedicines, 8, 530. (SCI)

  27. Guo, B.*, Zhu, N., Wang, W., Wang, H. (2020). Constructing exact tolerance intervals for the exponential distribution based on record values. Quality and Reliability Engineering International, 36, 7, 2398-2410 (SCI).

  28. Chen, Y.-H. and Wang, H.* (2020). Exploring Diversity of COVID 19 Based on Substitution Distance. Infection and Drug Resistance, 13:3887-3894 (SCI)

  29. Wang, H.* (2020). MicroRNAs and Apoptosis in Colorectal Cancer. International Journal of Molecular Sciences, 21(15), 5353. (SCI)

  30. Wang H.* (2020). Anti-NMDA Receptor Encephalitis: Efficacy of Treatment for Male Patients and miRNA Biomarker, Current Medicinal Chemistry, 27(24):4138-4151. (SCI) NMDA PDF  cover image

  31. Chen. C. and Wang, H.* (2020). Tolerance Interval for the Mixture Normal Distribution. Journal of Quality Technology, 52, 145–154. (SCI)

  32. Wang, H.* (2019). Vaccines and Neurological Disease. Current Pharmaceutical Design, 25(43): 4551. (SCI) PDF

  33. Guo,B.*, Zhu, N., Wang,W., Song,Y. and Wang, H. (2019). Exact two-sided tolerance interval controlling tail proportions for sample variances, Quality and Reliability Engineering International, to appear (SCI)

  34. Wang, H.* (2019). Anti-NMDA Receptor Encephalitis, Vaccination and Viruses. Current Pharmaceutical Design, 25(43),4579-88. (SCI) PDF

  35. Wang, H.* (2019). Phylogenetic Analysis to Explore the Association Between Anti-NMDA Receptor Encephalitis and Tumors Based on microRNA Biomarkers, Biomolecules, 9(10), 572. (SCI)

  36. Taguchi, Y.-H. and Wang, H.* (2018). Exploring MicroRNA Biomarkers for Parkinson's Disease from mRNA Expression Profiles. Cells, 7, 245. (SCI)

  37. Taguchi YH and Wang H.* (2018) Exploring microRNA Biomarker for Amyotrophic Lateral Sclerosis, International Journal of Molecular Sciences, 19, 1318. (SCI)

  38. Wang, H.* (2018). A protocol for investigating the association of vaccination and anti-NMDA receptor encephalitis. Frontiers in Bioscience (Scholar Edition), 10:229-237. NMDA

  39. Huang, W. H., Yeh, A. B.* and Wang, H. (2018). A Control Chart for the Lognormal Standard Deviation, Quality Technology & Quantitative Management, 15,1-36. (SCI)

  40. Taguchi YH and Wang H.* (2017)  Genetic Association between Amyotrophic Lateral Sclerosis and Cancer. Genes, 8, 243. (SCI)

  41. Wang, H. and Tsung, F. (2017). Constructing Tolerance Intervals for the Number of Defects Using both High and Low Resolution Data. Journal of Quality Technology, 49, 354-364. (SCI)

  42. Wang, H.* (2017). Anti-NMDA Receptor Encephalitis and Vaccination, International Journal of Molecular Sciences, 18, 193. (SCI) PDF NMDA

  43. Wang, H.* (2016). Predicting MicroRNA Biomarkers for Cancer using Phylogenetic Tree and Microarray Analysis, International Journal of Molecular Sciences, 17, 773. (SCI) PDF

  44. Wang *, Y.H. T. and Wang, H. (2016). On the Monitoring of Mixture Simple Linear Profiles, Journal of Statistical Computation and Simulation, 86, 3009–3024. (SCI)

  45. Huang, W. H., Wang, H.* and Yeh, A. B. (2016), Control Charts for the Lognormal Mean, Quality and Reliability Engineering International, 32, 1407–1416. (SCI)

  46. Wang, H.* (2016). Efficacies of treatments for anti-NMDA receptor encephalitis, Frontiers in Bioscience-Landmark, 21:651-63. (SCI) PDF NMDA

  47. Chen, W. and Wang, H.* (2015). Variance Estimation for Nucleotide Substitution Models. Molecular Phylogenetics and Evolution, 90, 97-103. (SCI) Codes   PDF

  48. Wang, H.*, Huwang, L. and Yu, J.H. (2015). Multivariate Control Charts Based on the James-Stein Estimator, European Journal of Operational Research, 246, 119-127. (SCI) PDF

  49. Wang, H.* (2014). Predicting Cancer-Related MiRNAs Using Expression Profiles in Tumor Tissue, Current Pharmaceutical Biotechnology, 15(5):438-444. (SCI) PDF

  50. Hsieh, W.J., Lin, F.M., Huang, H.D*. and Wang, H.* (2014). Investigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling, PLoS One, 9(4):e95697. (SCI)

  51. Wang, H.* and Huang, W. H. (2014). Bayesian Ranking Responses in Multiple Response Questions. Journal of the Royal Statistical Society, Series A (Statistics in Society), 177, 191–208, (SCI) PDF  

  52. Wang, H.* (2014). Confidence Intervals for A Bounded Mean in Exponential Families, Statistics, 48, 327-343. (SCI) PDF  

  53. Wang, H., Chiu, CC., Wu, TC. and Wu, WS.* (2013). Shrinkage regression-based methods for microarray missing value imputation. BMC Systems Biology, 7(Suppl 6):S11 (SCI)

  54. Hsieh, W.J. and Wang, H.* (2013). RRSM with a Data-dependent Threshold for miRNA Target Prediction. Journal of Theoretical Biology, 337, 54-60 (SCI)

  55. Lu, I.L. and Wang, H.* (2012). Protein-specific Scoring Method for Ligand Discovery, Journal of Computational Biology, 19(11): 1215-1226. (SCI) PDF   supplementary materials

  56. Wang, H.* and Hung, S. L. (2012). Phylogenetic Tree Selection by the Adjusted K-means Approach. Journal of Applied Statistics, 39, 643-655. (SCI) PDF

  57. Hsieh, W.J. and Wang, H.* (2011). Human MicroRNA Target Identification by RRSM. Journal of Theoretical Biology, 286, 79-84. (SCI) RRSM   PDF   supplementary materials

  58. Wang, H., Wang, YH. and Wu, WS.* (2011). Yeast cell cycle transcription factors identification by variable selection criteria. Gene, 485, 172-176 . (SCI) PDF

  59. Wang, H.* (2011). Confidence Intervals for the Substitution Number in the Nucleotide Substitution Models. Molecular Phylogenetics and Evolution, 60, 472–479. (SCI) PDF

  60. Wang, H.*, Lu, H. HS. and Chueh, TH. (2011). Constructing Biological Pathways by a Two-step Counting Approach. PLoS ONE, 6(6): e20074. doi: 10.1371/journal.pone.0020074 (SCI). PDF

  61. Wang, H.* (2010). Closed form prediction intervals applied for disease counts, The American Statistician, 64, 250-256. (SCI) PDF

  62. Emura, T. and Wang, H.* (2010). Approximate Tolerance Limits Under Log-location-scale Regression Models in the Presence of Censoring, Technometrics, 52, 313-323. (SCI) PDF

  63. Wang , H.* (2010). The Monotone Boundary Property and the Full Coverage Property of Confidence Intervals for a Binomial Proportion. Journal of Statistical Planning and Inference, 140, 495 -501. (SCI) PDF

  64. Wang, H.* (2009). Comparison of p Control Charts for Low Defective Rate. Computational Statistics & Data Analysis, 53, 4210-4220. (SCI) PDF

  65. Wang, H. and Li, W. H.* (2009). Increasing microRNA target prediction confidence by the relative r-squared method. Journal of Theoretical Biology, 259 , 793–798. (SCI) RRSM   PDF

  66. Wang, H. and Tsung, F.* (2009) . Tolerance Intervals with Improved Coverage Probabilities for Binomial and Poisson Variables. Technometrics, 51, 25-33. (SCI) Matlab Codes  PDF

  67. Wang, H.* (2009). Exact average coverage probabilities and confidence coefficients of confidence intervals for discrete distributions. Statistics and Computing, 19. 139-148. (SCI) PDF

  68. Cai, T.* and Wang, H. (2009). Tolerance Intervals for Discrete Distributions in Exponential Families. Statistica Sinica, 19, 905-923. (SCI)

  69. Wang, H.* (2008). Coverage probability of prediction intervals for discrete random variables. Computational Statistics & Data Analysis, 53, 17–26.(SCI) Matlab Codes  PDF

  70. Wang, H., Tzeng, Y.H. and Li, W.H.* (2008). Improved variance estimators for one- and two-parameter models of nucleotide substitution. Journal of Theoretical Biology, 254, 164-167. (SCI) PDF

  71. Chang, Y. P., Huang, W. T.* and Wang, H. (2008). ε-Admissible Estimators for Normal and Poisson Means. Communications in Statistics- Theory and Methods, 37, 1181-1192. (SCI)

  72. Wang, H.* (2008). Confidence Intervals for the Mean of a Normal Distribution with Restricted Parameter Space. Journal of Statistical Computation and Simulation, 78, 829–841. (SCI) PDF

  73. Wang, H.* (2008). Exact Confidence Coefficients of Simultaneous Confidence Intervals for Multinomial Proportions. Journal of Multivariate Analysis, 99, 896-911. (SCI) PDF

  74. Wang, H.* (2008). Ranking Responses in Multiple-Choice Questions. Journal of Applied Statistics, 35, 465-474. (SCI) PDF

  75. Wang, H.* (2007). Estimation of the probability of passing the USP dissolution test. Journal of Biopharmaceutical Statistics, 17, 407-413. (SCI) PDF

  76. Wang, H.* (2007). Modified p-values for one-sided testing in restricted parameter spaces. Statistics and Probability Letters, 77, 625-631. (SCI) PDF

  77. Wang, H.* (2007). Exact confidence coefficients of confidence intervals for a binomial proportion. Statistica Sinica, 17, 361-368. (SCI) R Codes  PDF

  78. Wang, H* (2006). Modified p-value of two-sided test for normal distribution with restricted parameter space. Communications in Statistics- Theory and Methods, 35, 1361-1374. (SCI) PDF

  79. Wang, H* (2006). Bayesian approach to estimation of accuracy in two-sided testing, Int. J. Contemp. Math. Sci.,1, 419-438.

  80. Wang, H.* (2005). Improved confidence estimators for confidence sets of location parameters. Journal of Statistical Planning and Inference, 128, 95-107. (SCI) PDF

  81. Wang, H.* (2004). Improved estimation of accuracy in simple hypothesis versus simple alternative testing. Journal of Multivariate Analysis, 90, 269-281. (SCI) PDF

  82. Wang, H.* (2002). Improved confidence estimators for the usual one-sided confidence intervals for the ratio of two normal variances. Statistics and Probability Letters, 59, 307-315. (SCI)

  83. Wang, H.* (2001). Admissibility of confidence estimators in the regression model. Journal of Multivariate Analysis, 76, 267-276. (SCI)

  84. Woodroofe, M.* and Wang, H. (2000). The problem of low counts in a signal plus noise model. Annals of Statistics, 28, 1561-1569. (SCI) PDF

  85. Wang, H.* (2000). Improved confidence estimators for the multivariate normal confidence set. Statistica Sinica, 10, 659-664. (SCI)

  86. Wang, H.* (1999). Brown's paradox in the estimated confidence approach. Annals of Statistics, 27, 610-626. (SCI) PDF

  87. Wang, H.* (1998). Estimated confidence under ancillary statistic everywhere valid constraint. Journal of Statistical Planning and Inference, 67, 123-135. (SCI)

  88. Wang, H.* (1998). Admissibility of the constant coverage probability estimator for estimating the coverage function of certain confidence interval. Statistics and Probability Letters, 36, 365-372. (SCI)

·         SOFTWARE